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| TAAR1 agonist ： ウィキペディア英語版 |
TAAR1
Trace amine-associated receptor 1 (TAAR1) is a protein that in humans is encoded by the ''TAAR1'' gene. TAAR1 is an amine-activated Gs- and G protein-coupled receptor (GPCR) that is located in several peripheral organs and circulating lymphocytes, as well as in astrocytes and within the presynaptic (i.e., axon terminal) plasma membrane of monoamine neurons in the central nervous system (CNS).〔〔 TAAR1 was discovered in 2001 by two independent groups of investigators, Borowski ''et al.'' and Bunzow ''et al.''〔〔 TAAR1 is one of six functional trace amine-associated receptors in humans, which are so named for their ability to bind low-concentration, endogenous monoamines called trace amines or closely related compounds.〔〔 TAAR1 plays a significant role in regulating neurotransmission in dopamine, norepinephrine, and serotonin neurons in the CNS;〔 it also affects immune system and neuroimmune system function through different mechanisms.〔〔〔〔
== Discovery ==
TAAR1 was discovered independently by Borowski ''et al.'' and Bunzow ''et al.'' in 2001. To find the genetic variants responsible for TAAR1 synthesis, they used mixtures of oligonucleotides with sequences related to G protein-coupled receptors (GPCRs) of serotonin and dopamine to discover novel DNA sequences in rat genomic DNA and cDNA, which they then amplified and cloned. The resulting sequence was not found in any database and coded for TAAR1.〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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